Help your body strengthen, protect, and rebuild joint tissues
- Helps strengthen cartilage and maintain structural integrity of joints and connective tissues*
- Protects joints from harmful free radicals that accelerate the breakdown of connective tissues*
- Provides nutrients for joint fluid, cartilage, ligaments, tendons, membranes and blood vessels*
- Increases lubrication and padding for improved mobility*
Build healthy joints for flexible, free movement
Life is great when we’re mobile, flexible and strong, but weak or sore joints can stop us in our tracks. SISEL is serious about improving our quality of life, and freedom of movement is a major factor. From kneeling in the garden or playing with children to competing in sports, aching joints can cramp our style. Even common activities such as sleeping, sitting at a desk, taking a walk, or standing erect can be challenging with stiff joints.
The scientists at SISEL have formulated Renovator, a powerhouse product, which supports our bodies’ mobility. Renovator combines glucosamine sulfate with Cynatine FLX™, a powerful new polypeptide extracted from keratin, to support healthy cartilage, plus zinc, selenium, and copper to nourish and build joint tissues, and manganese, beta-carotene, and vitamin C to reduce oxidative damage in our joints.
Many clinical trials have shown glucosamine sulfate to improve joint health, mobility, and flexibility, but may need additional ingredients to maximize its benefits. As we continue to take a daily dose, we assist our bodies in the proper maintenance of our connective and shock-absorbing tissues.1, 2, 3
Cynatine FLX™ helps to calm joint tissues, minimize joint breakdown, and build joint resilience. This new keratin joint ingredient activates two important joint antioxidant defense enzymes—glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD)—to improve the body’s ability to produce glutathione, the body’s own antioxidant defense mechanism. It also provides excellent, direct antioxidant protection and stimulates the regeneration of cells. Keratin is a polymer-forming protein, and joints use polymers to absorb shock and keep the joint together. Finally, Cynatine FLX™ is a fibrous protein that serves as structural units for various living tissues, providing a strong matrix for connective tissues.4, 5
Additionally, Renovator provides vitamins and minerals that contribute to joint health. Studies have shown that taking beta-carotene may reduce the risk of the progression of joint problems.6 Vitamin C is necessary to form collagen and is essential for the repair and maintenance of cartilage, thereby reducing the risk of joint problems.6 Manganese deficiency appears to be a factor in bone loss and degenerative joint conditions.7 Epidemiological studies show a relationship between low selenium and decreased joint health.8, 9 Zinc is involved in making up cartilage collagen.10, 11 Copper is needed for effective cross-linking of collagen and elastin.12
Whether from our active lifestyle or being overweight, our joints can take a beating. Our everyday wear and tear requires proper maintenance. Whether our neck, shoulders, elbows, wrists, fingers, spine, hips, knees, or ankles—our bodies will tell us which joint or connecting tissue is our weakest link. Don’t wait, but support them with Renovator. We count on our joints for support. How can we help them to keep us going? Renovator is the answer. Its combination of beneficial ingredients nourishes, protects, and strengthens our joints.
References:
1 Pavelka K, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. 2002 Oct 14:162(18):2113-23.
2 Bruyere O, et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 2004;11:138-43.
3 Reginster JY, et al. Long-term effects of glucosamine sulfate on osteoarthritis progression: a randomized, placebo-controlled trial. Lancet 2001;357:251-6.
4 A Ostalowska, E Birkner, M Wiecha, et al. Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint, Osteoarthritis and Cartilage, Volume 14, Issue 2, Pages 139-145
5 www.nutraingredients.com. A Pure, Potent Joint Health Alternative, includes links to Cynatine’s clinical and background documentation, 2005.
6 McAlindon TE, et al. Do antioxidant micronutrients protect against the development and progression of knee osteoarthritis? Arthritis Rheum 1996;39:648-56.
7 Das A Jr, Hammad TA. Efficacy of a combination of FCHG49 glucosamine hydrochloride, TRH122 low molecular weight sodium chondroitin sulfate and manganese ascorbate in the management of knee osteoarthritis. Osteoarthritis Cartilage. 2000 Sep;8(5):343-50.
8 Jellin, Jeff M. PharmD, Founding Editor. 3120 W. March Lane, PO Box 8190, Stockton, CA 95208, Tel:(209) 472-2244 Fax:(209) 472-2249. Copyright © 1995-2007 Therapeutic Research Faculty, All rights reserved.
9 Jordan JM, Fang F, Arab L, et al. Low selenium levels are associated with increased risk for osteoarthritis of the knee. American College of Rheumatology Annual Meeting. San Diego November 12-17, 2005. Abstract 1189.
10 Rosenberg K, et al. Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen. J Biol Chem. 1998 Aug 7;273(32):20397-403.
11 Leppanen VM, et al. Crystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain family. J Biol Chem. 2007 Aug 10:282(32):23219-30.
12 National Acadamies Press. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2000). Food and Nutrition Board (FNB). Institute of Medicine (IOM). Web: http://www.nap.edu/openbook.php?record_id=10026&page=224.
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